Michael Brudno

Faculty Member

Professor, Department of Computer Science, University of Toronto

Canada CIFAR Artificial Intelligence Chair

Chief Data Scientist, University Health Network

Michael Brudno is a Professor in the Department of Computer Science at the University of Toronto, as well as the Chief Data Scientist at the University Health Network (UHN). He is also a faculty member at the Vector Institute for Artificial Intelligence and the Scientific Director of HPC4Health, a private computing cloud for Ontario hospitals. His main research interest is the development of computational methods for the analysis of clinical and genomic datasets, especially the capture of precise clinical data from clinicians using effective user interfaces, and its utilization in the automated analysis of genomes. This work focuses on the capture of structured phenotypic data from clinical encounters, using both refined User Interfaces, and mining of unstructured data (based on Machine Learning methodology), and the analysis of omics data (genome, transcriptome, epigenome) in the context of the structured patient phenotypes, mostly for rare diseases. His overall research goal is to enable the seamless automated analysis of patient omics data based on automatically captured information from a clinical encounter, thus streamlining clinical workflows and enabling faster and better treatments.

After receiving a BA in Computer Science and History from UC Berkeley, Michael received his PhD from the Computer Science Department of Stanford University, working on algorithms for whole genome alignments. He completed a postdoctoral fellowship at UC Berkeley and was a Visiting Scientist at MIT. He is the recipient of the Ontario Early Researcher Award and the Sloan Fellowship, as well as the Outstanding Young Canadian Computer Scientist Award.

Research Interests

  • Computational Medicine
  • Computational Biology
  • Human-Computer Interaction


GA4GH: International policies and standards for data sharing across genomic research and healthcare

Heidi L Rehm and Angela JH Page and Lindsay Smith and Jeremy B Adams and Gil Alterovitz and Lawrence J Babb and Maxmillian P Barkley and Michael Baudis and Michael JS Beauvais and Tim Beck and Jacques S Beckmann and Sergi Beltran and David Bernick and Alexander Bernier and James K Bonfield and Tiffany F Boughtwood and Guillaume Bourque and Sarion R Bowers and Anthony J Brookes and Michael Brudno and Matthew H Brush and David Bujold and Tony Burdett and Orion J Buske and Moran N Cabili and Daniel L Cameron and Robert J Carroll and Esmeralda Casas-Silva and Debyani Chakravarty and Bimal P Chaudhari and Shu Hui Chen and J Michael Cherry and Justina Chung and Melissa Cline and Hayley L Clissold and Robert M Cook-Deegan and Mélanie Courtot and Fiona Cunningham and Miro Cupak and Robert M Davies and Danielle Denisko and Megan J Doerr and Lena I Dolman and Edward S Dove and L Jonathan Dursi and Stephanie OM Dyke and James A Eddy and Karen Eilbeck and Kyle P Ellrott and Susan Fairley and Khalid A Fakhro and Helen V Firth and Michael S Fitzsimons and Marc Fiume and Paul Flicek and Ian M Fore and Mallory A Freeberg and Robert R Freimuth and Lauren A Fromont and Jonathan Fuerth and Clara L Gaff and Weiniu Gan and Elena M Ghanaim and David Glazer and Robert C Green and Malachi Griffith and Obi L Griffith and Robert L Grossman and Tudor Groza and Jaime M Guidry Auvil and Roderic Guigó and Dipayan Gupta and Melissa A Haendel and Ada Hamosh and David P Hansen and Reece K Hart and Dean Mitchell Hartley and David Haussler and Rachele M Hendricks-Sturrup and Calvin WL Ho and Ashley E Hobb and Michael M Hoffman and Oliver M Hofmann and Petr Holub and Jacob Shujui Hsu and Jean-Pierre Hubaux and Sarah E Hunt and Ammar Husami and Julius O Jacobsen and Saumya S Jamuar and Elizabeth L Janes and Francis Jeanson and Aina Jené and Amber L Johns and Yann Joly and Steven JM Jones and Alexander Kanitz and Kazuto Kato and Thomas M Keane and Kristina Kekesi-Lafrance and Jerome Kelleher and Giselle Kerry and Seik-Soon Khor and Bartha M Knoppers and Melissa A Konopko and Kenjiro Kosaki and Martin Kuba and Jonathan Lawson and Rasko Leinonen and Stephanie Li and Michael F Lin and Mikael Linden and Xianglin Liu and Isuru Udara Liyanage and Javier Lopez and Anneke M Lucassen and Michael Lukowski and Alice L Mann and John Marshall and Michele Mattioni and Alejandro Metke-Jimenez and Anna Middleton and Richard J Milne and Fruzsina Molnár-Gábor and Nicola Mulder and Monica C Munoz-Torres and Rishi Nag and Hidewaki Nakagawa and Jamal Nasir and Arcadi Navarro and Tristan H Nelson and Ania Niewielska and Amy Nisselle and Jeffrey Niu and Tommi H Nyrönen and Brian D O’Connor and Sabine Oesterle and Soichi Ogishima and Vivian Ota Wang and Laura AD Paglione and Emilio Palumbo and Helen E Parkinson and Anthony A Philippakis and Angel D Pizarro and Andreas Prlic and Jordi Rambla and Augusto Rendon and Renee A Rider and Peter N Robinson and Kurt W Rodarmer


International federation of genomic medicine databases using GA4GH standards

Adrian Thorogood and Heidi L Rehm and Peter Goodhand and Angela JH Page and Yann Joly and Michael Baudis and Jordi Rambla and Arcadi Navarro and Tommi H Nyronen and Mikael Linden and Edward S Dove and Marc Fiume and Michael Brudno and Melissa S Cline and Ewan Birney


CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis

Matthew Osmond and Taila Hartley and David A Dyment and Kristin D Kernohan and Michael Brudno and Orion J Buske and A Micheil Innes and Kym M Boycott and Kym Boycott and Francois Bernier and Clara van Karnebeek and David Dyment and Kristin Kernohan and Micheil Innes and Ryan Lamont and Jillian Parboosingh and Deborah Marshall and Christian Marshall and Roberto Mendoza and James Dowling and Robin Hayeems and Bartha Knoppers and Anna Lehman and Sara Mostafavi


Automatically disambiguating medical acronyms with ontology-aware deep learning

Marta Skreta and Aryan Arbabi and Jixuan Wang and Erik Drysdale and Jacob Kelly and Devin Singh and Michael Brudno


Safety and efficacy of preventative COVID vaccines: The StopCoV Study

Sharon Walmsley and Leah Szadkowski and Bradly Wouters and Rosemarie Clarke and Karen Colwill and Paula Rochon and Michael Brudno and Rizani Ravindran and Janet Raboud and Allison McGeer and Amit Oza and Christopher Graham and Amanda Silva and Dorin Manase and Laura Parente and Jacqueline Simpson and Roaya Monica Dayam and Adrian Pasculescu and Anne-Claude Gingras


MetaFusion: a high-confidence metacaller for filtering and prioritizing RNA-seq gene fusion candidates

Michael Apostolides and Yue Jiang and Mia Husić and Robert Siddaway and Cynthia Hawkins and Andrei L Turinsky and Michael Brudno and Arun K Ramani


Grad2Task: Improved Few-shot Text Classification Using Gradients for Task Representation

Jixuan Wang and Kuan-Chieh Wang and Frank Rudzicz and Michael Brudno


Child Neurology: RNA Sequencing for the Diagnosis of Lissencephaly

Hebah Qashqari and Arun Ramani and Hernan Gonorazky and Kimberly Amburgey and Mohammad M Ghahramani Seno and Michael Brudno and Sergey Naumenko and Soma Das and James J Dowling


Assessment of Machine Learning–Based Medical Directives to Expedite Care in Pediatric Emergency Medicine

Devin Singh and Sujay Nagaraj and Pouria Mashouri and Erik Drysdale and Jason Fischer and Anna Goldenberg and Michael Brudno


Splicing is an alternate oncogenic pathway activation mechanism in glioma

Robert Siddaway and Scott Milos and Arun Kumaran Anguraj Vadivel and Tara HW Dobson and Jyothishmathi Swaminathan and Scott Ryall and Sanja Pajovic and Palak G Patel and Javad Nazarian and Oren Becher and Michael Brudno and Arun Ramani and Vidya Gopalakrishnan and Cynthia Hawkins


PhenoPad: Building AI enabled note-taking interfaces for patient encounters

Jixuan Wang and Jingbo Yang and Haochi Zhang and Helen Lu and Marta Skreta and Mia Husić and Aryan Arbabi and Nicole Sultanum and Michael Brudno


A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol

Anshika Jain and Ryan Huang and Jasmine Lee and Natasha Jawa and Yong Jin Lim and Mike Guron and Sharon Abish and Paul C Boutros and Michael Brudno and Bruce Carleton and Geoffrey DE Cuvelier and Lakshman Gunaratnam and Cheryl Ho and Khosrow Adeli and Sara Kuruvilla and Giles Lajoie and Geoffrey Liu and Paul C Nathan and Shahrad Rod Rassekh and Michael Rieder and Sushrut S Waikar and Stephen A Welch and Matthew A Weir and Eric Winquist and David S Wishart and Alexandra P Zorzi and Tom Blydt-Hansen and Michael Zappitelli and Bradley Urquhart


Creation of an electronic patient-reported outcome measure platform Voxe: a mixed methods study protocol in paediatric solid organ transplantation

Samantha J Anthony and Sarah J Pol and Jia Lin and Melanie Barwick and Michael Brudno and Dorin Manase and Rulan Savita Parekh and Amanda Silva and Jennifer Stinson


Outcome of over 1500 matches through the Matchmaker Exchange for rare disease gene discovery: The 2-year experience of Care4Rare Canada

Matthew Osmond and Taila Hartley and David A Dyment and Kristin D Kernohan and Michael Brudno and Orion J Buske and A Micheil Innes and Kym M Boycott and Kym Boycott and Francois Bernier and Clara van Karnebeek and David Dyment and Kristin Kernohan and Micheil Innes and Ryan Lamont and Jillian Parboosingh and Deborah Marshall and Christian Marshall and Roberto Mendoza and James Dowling and Robin Hayeems and Bartha Knoppers and Anna Lehman and Sara Mostafavi